In the high-risk group, the samples had lower proportions of infiltrating B cells naive, Monocytes, Mast cells resting, Macrophages M2, T cells CD4 memory resting, T cells CD8, and higher proportions of infiltrating Dendritic cells activated, Macrophages M0, Macrophages M1, T cells follicular helper, which might account for the prognostic difference in BC patients from these two subgroups. The gene discussed is CD8A; the disease is breast cancer.