Studies that have investigated the role of DEPTOR in cancer indicate that DEPTOR levels are generally low across several tumor types (Caron et al., 2018), and that rescue of DEPTOR is an effective anti-cancer therapy (Xiong et al., 2018; Cuesta et al., 2019), warranting further study of this novel protein in mTOR-dependent processes. The gene discussed is MTOR; the disease is cancer.