PAX6 and isolated aniridia: The loss of one Pax6 allele, such as seen in the context of the rare disease called aniridia, characterized by an hypoplasia or lack of iris, as well as Pax6 overexpression, showed overlapping effects such as reduced krt12 expression, reduced adult corneal diameter or thickness, and altered wound healing (Ramaesh et al., 2003; Dora et al., 2008).