However, in a follow-up study of a triple transgenic mouse model of Alzheimer’s disease expressing both amyloid and tau pathology (3xTg mice), 28Si or 56Fe ion irradiation at either 10 cGy or 100 cGy did not alter either amyloid or tau pathology (Owlett et al., 2020). This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.