Hypertension is associated with activation of the renin-angiotensin system and elevated Angiotensin II (Ang II) levels are associated with the development of AF (Khatib et al., 2013; Heijman et al., 2014; Jansen et al., 2020; Nattel et al., 2020; Aguilar et al., 2021). This evidence concerns the gene AGT and Hypertension.