Indeed, analysis of mutant mice lacking CB1 expression in cortical glutamatergic neurons and viral deletion strategies have demonstrated a relevant role of this receptor population in mediating neuroprotection (Monory et al., 2006), motor impairment and hypothermia (Monory et al., 2007), fear memories (Metna-Laurent et al., 2012), stress-induced social alterations (Dubreucq et al., 2012), and anxiety (Rey et al., 2012). Here, CNR1 is linked to Anxiety.