GLP1R and heart failure: In in vivo and in vitro models of myocardial ischemic injury, GLP-1 prevents cardiac insufficiency, reduces infarct size, and protects coronary vascular cells from oxidative stress injury, and its cardioprotective effects may be related to GLP-1R-mediated inactivation of the cAMP/PKA pathway and, subsequently, the RAGE/Rho/ROCK and MAPK signaling pathways [11, 12].