It was recently found that in the eutopic endometrium of patients with endometriosis, downregulation of H19 will increase let-7 activity, contributing to a decreased proliferation of endometrial stromal cells (through IGFR1 expression inhibition) and contributing to the impaired endometrial preparation and receptivity (through reduction of stromal cell proliferation) (348). Here, H19 is linked to endometriosis.