In the context of impaired endometrial receptivity and progesterone resistance, Petracco et al. (345) identified a putative miR135 binding site in HOXA10 gene showing that miR135a and miR135b are expressed in normal endometrium and increased in the endometrium of women with endometriosis; they likely act by regulating targets of progesterone action in the endometrium. This evidence concerns the gene HOXA10 and endometriosis.