The results suggested that after adjusting gender, age, DBP, SBP, BMI, HDL-C, TG, LDL-C, TC, Scr, FPG, BUN, drinking status, smoking status and family history of diabetes, AST/ALT ratio was negatively correlated with prediabetes risk (HR:0.78, 95%CI: 0.73-0.84) (Table 5). The gene discussed is GPT; the disease is diabetes mellitus.