(34) found that when the AST/ALT ratio was ≤0.93, the AST/ALT ratio was negatively associated with incident diabetes (HR:0.14, 95%CI:0.02–0.90, P=0.0385) after adjustment for age, sex, BMI, regular exerciser, waist circumference, smoking, alcohol consumption, γ-glutamyl transpeptidase, HDL-C, TC, TG, HBA1C, FBG, SBP, DBP, fatty liver, AST and ALT. The gene discussed is GPT; the disease is diabetes mellitus.