NLRP3 and Hyperglycemia: For example, hyperglycemia promoted cardiomyocyte pyroptosis by activating the AMPK-TXNIP/NLRP3 signaling pathway (134, 181), and pyroptosis-associated TLR4 and NLRP3 inflammasome expression was increased in HG-treated H9C2 cardiomyocytes (182).