NLRP3 and type 2 diabetes mellitus: In type 2 diabetes, A variety of metabolites and factors such as glucose and fatty acids (107), LPS released by the gut microbiota (108, 109), mitochondrial reactive oxygen species (mROS) (110), the international association for preventive pediatrics(IAPP) (111), ceramide (112), amino acid homocysteine (113) and ATP (114) can activate the NLRP3 inflammasome.