For example, current studies are all animal models or cell experiments, which are not enough to support targeting the NLRP3 inflammasome to prevent and treat T2D; in addition, the proportion of pyroptosis mediated by the NLRP3 inflammasome in the progression of diabetes is yet unknown, and the research on intervening the mechanism of pyroptosis to delay the progression of T2D is still challenging. The gene discussed is NLRP3; the disease is diabetes mellitus.