Univariate Cox regression analysis was further applied to assess the prognostic value of DEFRGs, and we found that 4 DEFRGs (APOE, P = 0.004; TSC22D1, P = 0.025; TIMP1, P = 0.029; HTRA3, P = 0.007) may act as independent factors for overall survival of thyroid cancer (Figure 3D). Here, HTRA3 is linked to thyroid cancer.