The upregulated inflammatory proteins in lipedema sorted by lowest adjusted p-value consisted of TNFSF14, CASP8, EN-RAGE (S100-A12), EIF4EBP1, ADA, MCP-1, SIRT2, CXCL11, CCL3, STAMBP, CD6, MCP-3, CCL4, MCP-2, ST1A1, IL-8, LAP TGF-beta-1, AXIN1, MCP-4, TGF-alpha, VEGFA (Figure 2A; Table 3). The gene discussed is CASP8; the disease is Lipedema.