Statistically significant association between serum Sparcl1 and dyslipidemia was observed in the subgroups of women (OR, 0.88; 95%CI, 0.78-0.99), current non-smokers (OR, 0.86; 95%CI, 0.77-0.97), high education (OR, 0.76; 95%CI, 0.59-0.98), physically inactive (OR, 0.88; 95%CI, 0.78-0.98), and BMI≥25kg/m2 (OR, 0.83;95% CI, 0.72-0.96). The gene discussed is SPARCL1; the disease is metabolic syndrome.