NF1 is an autosomal dominant genetic syndrome due to mutations in the NF1 tumor suppressor gene and is characterized by café au lait spots, dermal and plexiform neurofibromas, pheochromocytomas, optic gliomas, and malignant peripheral nerve sheath tumors (46, 47). The gene discussed is NF1; the disease is hereditary pheochromocytoma-paraganglioma.