Previous scholars found the serum OPN level in the menopausal females was 15.4 (ng/ml) compared to non-menopausal females with a lower OPN level of 7.8 (ng/ml), moreover, the higher OPN level also indicated an approximately 2.97-fold risk of osteoporosis compared with the persons with low serum OPN levels (12). The gene discussed is SPP1; the disease is osteoporosis.