While comparisons of the magnitude of the effects in different exercise studies should be done with caution due to differences in methodology, our HIIT-protocol did seem to increase insulin sensitivity ~2-fold more than previously observed after endurance training in individuals with type 2 diabetes or obesity (4, 28), and, importantly, there was no evidence of exercise resistance. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.