In this study, based on a GCK-MODY group with a larger sample size and retrospective groups of patients with type 1 diabetes (T1D), type 2 diabetes (T2D), and hepatocyte nuclear factor-1 alpha (HNF1A)-MODY, we aimed to further compare the blood lipid profiles of patients with GCK-MODY with those in other hyperglycemia groups and to explore whether inflammatory processes are associated with the lipid indices. This evidence concerns the gene HNF1A and type 2 diabetes mellitus.