Further, Oh et al. found that regulation of the dynamic chromatin architecture of the epidermal differentiation complex is modulated by cJun/AP-1 binding and responds to developmental signals at the onset of differentiation in mouse embryos [51], while Ibrahim et al. showed that Nanog was overexpressed in colorectal cancers via cJun/TCF4-mediated transcriptional activation [34]. This evidence concerns the gene JUN and colorectal cancer.