Current theories for the causes type 2 diabetes were attributed to the insulin-mediated deficiency of glucose uptake in muscle; impaired insulin action in the liver and disruption of adipocyte secretion, etc. α -Glucosidase is an enzyme that plays a crucial part in the final step of the digestion process, breaking down complex carbohydrates such as starch and glycogen into monomers. This evidence concerns the gene INS and type 2 diabetes mellitus.