HSP90B1 depletion reduced the phagocytic capacity of macrophages against Klebsiella pneumonia (K. pneumonia) (a common gram-negative bacteria that can cause pneumonia) and inhibited pro-inflammatory mediator release in alveolar and peritoneal macrophages treated with LPS derived from K. pneumonia or heat-killed K. pneumonia (88). Here, HSP90B1 is linked to susceptibility to pneumonia measurement.