ITGB1 and inflammation: It has been reported that ITGB1 mediated the entry of coronavirus severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) (96) and the conditional depletion of ITGB1 in type 2 alveolar epithelial cells could trigger emphysema, epithelial dysfunction, increased efferocytosis and pulmonary macrophage infiltration, and widespread lung inflammation in mice (97).