Among the 46 metabolic pathways-related proteins (28 up-regulated and 18 down-regulated), alpha-enolase (ENO1), neutrophil gelatinase-associated lipocalin (LCN2), and Acetyl-CoA acetyltransferase (ACAT1) have been found to be related to pathogens-induced pneumonia. The gene discussed is ENO1; the disease is pneumonia.