Results suggested that 5 proteins with greater node degrees [i.e. catenin beta-1 (CTNNB1), integrin beta-1 (ITGB1), catenin alpha-1 (CTNNA1), dynamin-2 (DNM2), Keratin, type I cytoskeletal 19 (KRT19)] might function as crucial players in pneumonia-related bacterial infection in FMD. This evidence concerns the gene ITGB1 and susceptibility to pneumonia measurement.