For instance, THBS1 loss reduced mouse survival rate, increased lung bacterial burden and lung microvascular permeability, impaired host defense against Pseudomonas aeruginosa (P. aeruginosa), and potentiated inflammatory injury during P. aeruginosa acute intrapulmonary infection (87), while P. aeruginosa is a common pathogen of pneumonia in FMD (17). Here, THBS1 is linked to pneumonia.