DHFR and cancer: The cancer target PDB ID 1RY0 (AKR1C3) showed the highest interactions with the majority of the NCs, followed by 1HFQ (DHFR), 3ZGC (NFE2L2), 4AF3 (AURKB), 4K33 (FGFR3), 5P21 (HRAS), 2I0V (CSF1R), and 3ZIM (PIK3CA) protein targets and least interaction was found with the 1M9Z (TGFBR2) protein.