According to the results of compound-target-protein network analysis, proteins with high degree including AKR1C3, DHFR, NFE2L2, AURKB, CD44, PIK3CA, FGFR3, CSF1R, and HRAS were identified as key targets of Clerodendrum in the treatment of cancer that which could intervene the potential pathway such as pathway in cancer, PI3K-Akt signaling pathway, proteoglycans in cancer, MAPK signalling pathway, focal adhesion, and prostate cancer for treating cancer in future. Here, DHFR is linked to prostate cancer.