For instance, neutrophils in COPD patients and COPD model rats are recruited to the lung and airway and secrete various serine proteases, including myeloperoxidase (MPO), matrix metalloproteinase (MMP), and neutrophil elastase (NE), all of which are related to destruction of the alveolar airway and cause emphysema [27]. Here, ELANE is linked to chronic obstructive pulmonary disease.