Contemporary studies have also demonstrated that ZWD can improve proteinuria and renal damage in rats with streptozotocin-induced diabetic nephropathy [40], alleviate cisplatin-induced acute kidney injury [41], protect against IgA nephropathy by regulating exosomes to inhibit the NF-kB/NLRP3 pathway [42], and mitigate podocyte injury in rats with IgA nephropathy through the PPARγ/NF-κB pathway [43]. This evidence concerns the gene NLRP3 and acute kidney injury.