Cancer cells with early ferroptosis can effectively induce ICD in vivo and in vitro by activating bone marrow-derived dendritic cells BMDCs and triggering DAMP (e.g. ATP and HMGB1), resulting in protective immunity against the attack on cancer cells, which boost the development of anti-cancer immunotherapy strategies based on ferroptosis cell vaccination (Efimova et al., 2020). The gene discussed is HMGB1; the disease is cancer.