It is reported that in the prognosis model of hepatocellular carcinoma, the genes (NFS1, CISD1, ACSL3, NQO1, SLC7A11, GPX4) that can protect hepatocytes with ferroptosis and the genes (ACACA, CARS, G6PD, SLC1A5) that induce ferroptosis are all up-regulated in HCC, and are related to poor prognosis (Liang et al., 2020). This evidence concerns the gene CISD1 and hepatocellular carcinoma.