To test the hypothesis that the reduction of KIF5B alone can decrease tau accumulation, neurodegeneration, and memory impairment, we partially reduced the levels of KIF5B in P301S tau mutant mice (P301S), a mouse model of AD and FTPD-17, which develops extensive tau pathology throughout the nervous system with high accumulation of phospho tau filaments resembling those of human tauopathies (Allen et al., 2002). Here, KIF5B is linked to Alzheimer disease.