MAPT and Cerebral ischemia: The finding that KIF5B knockdown or knockout in cell cultures and cultures increased the protein stability of WT tau was consistent with the findings of another study that showed that the reduction of KIF5B can be neuroprotective in the mouse cerebral ischemia preconditioning model, especially by disturbing the interaction of KIF5B and the NMDA receptor subunit GluN2B (Lin et al., 2019).