Vascular endothelial growth factor A (VEGF-A) was chosen as a suitable candidate for the functional analysis for two major reasons: first, to confirm that TAMs have a role in metastasis through VEGF-A, highlighting that the role of TAMs in metastasis is functionally analyzed for the first time, and the second reason was that VEGF-A is considered a reflection for the metastasis thus tumorigenesis, and this will confirm whether MALAT1 and HOTAIR are oncogenic or tumor suppressor. Here, MALAT1 is linked to neoplasm.