HOTAIR and breast cancer: To observe the impact of knocking down of MALAT1 and HOTAIR in TAMs of the three BC subtypes (hormonal, HER2+, and TNBC), the correlation between MALAT1 and HOTAIR was first observed showing that on the silencing of HOTAIR, MALAT1 was downregulated in all subtypes of BC, as shown in Figure 4, suggesting that HOTAIR may be an upstream regulator for MALAT1.