Mutations in the NLRP3 gene play an important role in several diseases, including gouty arthritis and type I diabetes (Pontillo et al., 2010; Zhang et al., 2018), and the expression of NLRP3 inflammatory complex-related genes (NLRP3, ASC, and CASP1) in peripheral blood mononuclear cells (PBMCs) may play an important role in RA pathogenesis and disease activity (Cheng et al., 2021). This evidence concerns the gene NLRP3 and gout.