Variations in the NLRP1 gene increase NLRP1 expression, which is a risk factor for the development of inflammatory diseases, including RA, type 1 intrinsic diabetes, vitiligo, and associated autoimmune diseases (Jin et al., 2007; McInnes and Schett 2011; Sui et al., 2012; Levandowski et al., 2013). The gene discussed is NLRP1; the disease is vitiligo.