The activity and expression of NLRP3 are upregulated in RA patients, which further suggests that the NLRP3 inflammatory complex may play an essential role in RA pathogenesis (Mathews et al., 2014; Choulaki et al., 2015; Ruscitti et al., 2015; Kim H et al., 2017; Addobbati et al., 2018). Here, NLRP3 is linked to rheumatoid arthritis.