CASP1 and rheumatoid arthritis: Mutations in the NLRP3 gene play an important role in several diseases, including gouty arthritis and type I diabetes (Pontillo et al., 2010; Zhang et al., 2018), and the expression of NLRP3 inflammatory complex-related genes (NLRP3, ASC, and CASP1) in peripheral blood mononuclear cells (PBMCs) may play an important role in RA pathogenesis and disease activity (Cheng et al., 2021).