Reduced levels of miR-20a (Jin et al., 2021) and miR-21 (Dong et al., 2014; Guggino et al., 2018) aggravate RA by triggering the NLRP3 inflammasome pathway and boosting STAT3 expression, while lowering STAT5 expression, both of which are linked with an imbalance of Th17/Treg cells (Huang Q et al., 2018). This evidence concerns the gene NLRP3 and rheumatoid arthritis.