However, PSA is organ- but not tumor-specific biomarker with low specificity and high false-positive rate in patients with benign prostatic hyperplasia (BPH) (18, 19).Therefore, we studied weather hsa-miR-133a-3p, miR-1-3p, GOLPH3, JUP or a combination of them, resulted in a good biomarker to distinguish between PCa and non-PCa patients. This evidence concerns the gene KLK3 and posterior cortical atrophy.