Of the eight HOX genes (HOXB1, HOXA7, HOXB5, HOXD8, HOXD9, HOXB9, HOXA9, and HOXA11) comprised in our signature, their transcript levels were consistently lower in ccRCC tissues compared to adjacent normal tissues (except for HOXD9). The gene discussed is HOXD8; the disease is nonpapillary renal cell carcinoma.