In training cohort, the HOX family genes were subjected to LASSO regression analysis followed by multivariate Cox analysis (Figures 2A–B), and eight HOX genes (HOXB1, HOXA7, HOXB5, HOXD8, HOXD9, HOXB9, HOXA9, and HOXA11) were finally retained to construct a prognosis signature in ccRCC. The gene discussed is HOXB1; the disease is nonpapillary renal cell carcinoma.