As shown in Figures 10A-G, the transcript levels of HOXB1, HOXA7, HOXB5, HOXD8, HOXB9, HOXA9, and HOXA11 were significantly lower in ccRCC tumor tissues compared to adjacent normal tissues, which was consistent in both TCGA and ICGC cohorts. This evidence concerns the gene HOXD8 and nonpapillary renal cell carcinoma.