Subsequently, we built a prognostic signature based on eight HOX genes including HOXB1, HOXA7, HOXB5, HOXD8, HOXD9, HOXB9, HOXA9, and HOXA11 in ccRCC for risk stratification, which allowed patients with higher or lower risk score to be divided into different risk groups. The gene discussed is HOXD8; the disease is nonpapillary renal cell carcinoma.