Among the fourteen HOX genes, nine genes (HOXA2, HOXA13, HOXA3, HOXB13, HOXA1, HOXA11, HOXC4, HOXC11, and HOXD10) were risk factors (Hazard Ratio >1) and the other six genes (HOXD1, HOXD3, HOXD8, HOXC10, and HOXA7) were protective factors (Hazard Ratio<1) in ccRCC (Figure 1C). This evidence concerns the gene HOXC4 and nonpapillary renal cell carcinoma.