Meanwhile, hallmarks including adherens junction, fatty acid metabolism, propanoate metabolism, TGF-β signaling pathway, tight junction, valine leucine and isoleucine degradation, and WNT signaling pathway were significantly enriched in ccRCC samples of low-risk group in TCGA cohort (Figure 7F). Here, TGFB1 is linked to nonpapillary renal cell carcinoma.