In ccRCC, although some studies have indicated that dysregulation of HOX genes such as HOXD1, HOXA13, and HOXC11 were associated with cell proliferation, metastasis, and apoptosis (27–29), while the detailed roles of HOX family genes on malignant behaviors of ccRCC and its prognostic values remained largely to be characterized. This evidence concerns the gene HOXD1 and nonpapillary renal cell carcinoma.