PDHA1 and cancer: In this study, TME analysis revealed that MTF1, NLRP3, and SLC31A1 were significantly positively correlated with TME scores (ImmuneScore, StromalScore, and ESTIMATEScore) in most human cancers, whereas ATP7B, DLAT, DLD, LIAS, PDHA1, and PDHB were significantly negatively correlated with the scores in most human cancers (Figure 8; details are provided in Table S4).