Prognostic analysis for OS, DSS, and PFS revealed that hypomethylation of DLAT, FDX1, MTF1, NLRP3, and PDHA1 was associated with low survival in most cancers, whereas hypermethylation of FDX1 and PDHB was associated with low survival in UVM(P < 0.05, Supplementary Figure S3). Here, PDHA1 is linked to cancer.