In this study, we investigated the differential expression of CRGs (ATP7A, ATP7B, DLAT, DLD, FDX1, GLS, LIAS, LIPT1, MTF1, NLRP3, PDHA1, PDHB, and SLC31A1) in cancer versus healthy tissues and healthy tissues versus cancer cell lines using the transcriptomic data derived from 33 different tumors, healthy tissues, and cancer cell lines in TCGA, GTEx, and CCLE datasets, respectively. The gene discussed is FDX1; the disease is cancer.