In this study, we investigated the differential expression of CRGs (ATP7A, ATP7B, DLAT, DLD, FDX1, GLS, LIAS, LIPT1, MTF1, NLRP3, PDHA1, PDHB, and SLC31A1) in cancer versus healthy tissues and healthy tissues versus cancer cell lines using the transcriptomic data derived from 33 different tumors, healthy tissues, and cancer cell lines in TCGA, GTEx, and CCLE datasets, respectively. This evidence concerns the gene LIPT1 and cancer.