To assess the mutation of CRGs in pan-cancer, we conducted an in-depth study using the cBioPortal database and found that the mutation frequency of ATP7A, ATP7B, DLAT, DLD, FDX1, GLS, LIAS, LIPT1, MTF1, NLRP3, PDHA1, PDHB, and SLC31A1 was 2.7%, 4%, 1.7%, 1.9%, 1.2%, 1.7%, 1%, 0.9%, 2.1%, 6%, 1.7%, 1.1.%, 0.7%, respectively. Here, LIAS is linked to cancer.