In addition, TMEM158 upregulation was also noticed in other types of human cancers, as reported by others (6, 8, 10–14), including cholangiocarcinoma, esophageal carcinoma, head and neck squamous cell carcinoma, lung adenocarcinoma and squamous cell carcinoma, rectum adenocarcinoma, and stomach adenocarcinoma (Supplemental Figure S2). The gene discussed is TMEM158; the disease is cancer.