In addition, TMEM158 upregulation was also noticed in other types of human cancers, as reported by others (6, 8, 10–14), including cholangiocarcinoma, esophageal carcinoma, head and neck squamous cell carcinoma, lung adenocarcinoma and squamous cell carcinoma, rectum adenocarcinoma, and stomach adenocarcinoma (Supplemental Figure S2). Here, TMEM158 is linked to cholangiocarcinoma.