It has been found that the lncRNA NEAT1 disrupted hepatocellular carcinoma lipolysis by regulating adipose triglyceride lipase, thereby driving hepatocellular carcinoma proliferation (16).In conclusion, LncRNAs are involved in the regulation of various lipid metabolism-related genes in cancer cells (17–21). Here, PNPLA2 is linked to hepatocellular carcinoma.