Intercellular adhesion molecule 1 (ICAM-1), signal transducer and activator of transcription (STAT)3, programmed cell death-ligand 1 (PD-L1), and microRNA-20a with its targeted proteins expressed by LSECs also play a pivotal role in the interaction between LSECs and cancer cells and thereby promote liver metastasis (64). This evidence concerns the gene CD274 and cancer.