TNF-α or IL-1 stimulate the attachment of tumor cells to LSECs and lead extravasation (49–51); LSECs secret fibronectin induce EMT and promote metastasis (72); CXCL12, ICAM-1, STAT3, PD-L1 and microRNA-20a expressed by LSECs interact with cancer cells and involve in liver metastasis (64). This evidence concerns the gene ICAM1 and neoplasm.