Gene set enrichment analysis (GSEA) revealed that numerous pathways were activated in high-risk patients, and these pathways were mainly involved in Focal adhesion, ECM receptor interaction, Gap junction, Hedgehog signaling pathway, MAPK signaling pathway, and JAK-STAT signaling pathway, suggesting that these CRLs may be directly related to the development of gastric cancer. This evidence concerns the gene SOAT1 and gastric cancer.