MKI67 and neoplasm: According to the pathological MP grading of neoadjuvant chemotherapy, RESIST grading of imaging target lesions before and after treatment, and histological grading, molecular type, age, tumor stage before treatment, and Ki-67 expression levels were stratified, and the association between the changes of these clinical indicators and the difference of hsa_circ_0058514 before and after treatment was analyzed.