In addition, since platelets express integrins while vascular endothelial cells also express the L1CAM (41), and L1CAM–integrin interactions can occur in trans(between different cells) (15), it is feasible that L1CAM–integrin signaling will contribute to significant platelet adhesion and tumor-associated thrombosis, which is thought to be important for the tumor cell arrest and migration in blood circulation when tumor cells detach from the primary site and intravasate into blood vessels (42, 43). Here, L1CAM is linked to neoplasm.