miR-181 significantly inactivated the sirtuin 1 (SIRT1)/peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α)/nuclear factor erythroid 2-related factor 2 (Nrf2) signaling cascade in CPF-treated neuroblastoma cells. The gene discussed is NFE2L2; the disease is neuroblastoma.