miR-125b overexpression or FOXP3 knockdown abrogated the pro-pyroptotic effect of tanshinone IIA on NPC cells, as evidenced by decreased levels of cleaved products of pyroptosis-related proteins including caspase-1, GSDMD-N, IL-1β and IL-18, as well as reduced release of ROS and LDH. The gene discussed is FOXP3; the disease is nasopharyngeal carcinoma.