As illustrated by Figure 1C, CLL population C (ROR-1lo/-CD5lo/-CD79bhi) displayed a polyclonal CDR3 length spectrum while population B (ROR-1lo/-CD5hiCD79blo) displayed the same monoclonal CDR3 peak size as the ROR-1+ leukemic clone (population A). The gene discussed is ROR1; the disease is B-cell chronic lymphocytic leukemia.