Baseline EGFR T790M mutation detection in ctDNA might correlate with a larger baseline tumor size (56 mm for T790M (+) versus 39 mm for T790M (-); P < 0.0001) and a higher probability of extra thoracic metastasis [58% M1b for T790M (+) versus 39% M1b for T790M (-); P = 0.002] (80). This evidence concerns the gene EGFR and neoplasm.