In recent years, a large number of studies have shown that ALDH1 is also closely related to other solid tumors.The overexpression of ALDH1 is associated with a poor prognosis and malignant tumor development, such as melanoma (204), glioma (205), prostate cancer (206, 207), endometrial cancer (6, 208), bladder cancer (209), Osteosarcoma (210), pancreatic cancer (211, 212), kidney cancer (213), etc. ALDH1, overexpressed in melanoma, promotes tumor angiogenesis mainly by activating IL-8/Notch signaling (214). The gene discussed is ALDH1A1; the disease is osteosarcoma.