An increased percentage of CD4+ cells was seen in all tissues from women as compared to men, with more CD4+ in the tumor (22.04% vs. 10.26%, p=0.002), lymph nodes (39.54% vs 8.56%, p=0.001), and a modest but still significant increase of CD4+ cells in surrounding uninvolved colonic tissue (3.91% vs 2.72%, p=0.045) (Figure 2A-C). Here, CD4 is linked to neoplasm.