Interestingly, the shifts in Treg and anti-tumor T cell expression were accompanied by increased expression of the exhaustion markers PD-L1 (3.83-fold, p=0.011), TIGIT (3.61-fold, p=0.011), and tumor suppressor FBP1 (9.23-fold, p=0.013) in women. The gene discussed is CD274; the disease is neoplasm.