Sensing of the dsRNA that is produced as a replicative intermediate during reovirus infection and is done by host PRRs such as retinoic acid-inducible gene I (RIG-I), melanoma differentiation-associated protein 5 (MDA-5), toll-like receptor 3 (TLR3) and NOD-like receptor protein 3 (NLRP3) leading to the induction of the innate immune response via the type I interferon pathway (37). The gene discussed is TLR3; the disease is Reoviridae infectious disease.