IFN-γ regulates the expression of ACSL4 (Acyl-CoA synthetase long chain family member 4) directly through STAT1-IRF1 signaling pathway, while arachidonic acid induces ferroptosis in tumor cells through preferential integration of ACSL4 into phospholipids containing C16 and C18 acyl chains. This evidence concerns the gene IFNG and neoplasm.