SHPK and glioma: Furthermore, SHK can induce Bcr/Abl-positive chronic myelogenous leukemia cell apoptosis and renal cancer cell autophagy via reactive oxygen species (ROS) generation (13, 14), in addition to promoting necroptosis in sunitinib-resistant renal cell carcinoma, glioma, docetaxel-resistant prostate cancer, and non-small cell lung cancer (15–17).