EGFR and neoplasm: Cetuximab (CTX), a clinically recommended EGFR inhibitor, mainly binds to the extracellular ligand-binding domain of EGFR with high affinity and interferes with the binding of other endogenous ligands to EGFR, thereby inhibiting the activity of EGFR downstream signaling and tumor cell proliferation as well as inducing apoptosis in cancer cells (2).