Notably, the salivary levels of anti-p53, anti-ANXA2, anti-ISG15, and anti-MMP1 in the overall pathological stage I-II and the TNM-N0 cancer groups were higher than that in the control groups, while the salivary levels of the above four auto-Abs were not significantly distinguishable between the groups of late-stage OSCC patients and the healthy individuals (Table 2, Supplementary Figures S4 and S6). This evidence concerns the gene TP53 and cancer.