Some heptamethine cyanine dyes can also preferentially accumulate in the mitochondria of tumor cells through the high expression of organic anion transporter peptides (OATPs) in tumors and the higher transmembrane potential of tumor cells (52, 53), and they can achieve tumor seeking, accumulation and retention via the covalent binding of meso-chlorine and albumin (54). Here, ALB is linked to neoplasm.