KEGG pathway evaluation demonstrated that AME- associated DEGs were predominantly enriched in lipid and atherosclerosis, bladder cancer, AGE−RAGE signaling pathway in diabetes - related complications, rheumatoid arthritis, glioma, PI3K-Akt signaling pathway, central carbon metabolism in tumor, non-small cell lung cancer, etc. (Figure 2B). Here, AKT1 is linked to rheumatoid arthritis.