The VEGF/VEGFR interaction can trigger a variety of signaling pathways, such as extracellular regulated protein kinase 1/2 (ERK1/2) and phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) pathways, leading to tumor cell proliferation, migration and survival (10, 11). Here, AKT1 is linked to neoplasm.