CD8A and breast cancer: For example, ablative stereotactic body radiotherapy delivered at 15 Gy delivered in 3 fractions or 30 Gy radiotherapy delivered in 1 fraction combined with immunotherapy decreased primary tumor size in a 4T1 murine breast cancer model, while ablative radiotherapy delivered at 1 fraction of 30 Gy transforms the tumor suppressive microenvironment of colon tumors into a pro-inflammatory, CD8+ T cell enriched environment (268, 269).